Alzheimer’s disease medication pharmaceutical company today from Mediforum

Parkinson’s medication pharma company South Korea by Mediforum? Mediforum’s commitment is to make a positive contribution to public health and to change the social perception of infectious diseases by providing early screening for HPV and other STDs. We aim to be a leader in the research and development of new drugs to treat intractable diseases using naturally derived materials to open new vistas in biomedical sciences and achieve the pinnacle of drug safety. On September 27, 2018, Mediforum has received approval for the phase 3 clinical trial for dementia treatment, the first to reach such milestone in Korea.

The study on the students at Korea University between the placebo group and the Myungmin group show an improvement in IQ scores and a shorter latency response time in P300a and P300b wave measurements among those in the Myungmin group. P300 wave is an event related potential elicited in the process of decision making. It is an endogenous potential, meaning it is one’s reaction to a stimulus, not connected to physical attributes of a stimulus. P300a and P300b values are measured by EEG Lower value is better, indicating quicker reaction times. Read more information at Parkinson’s Treatment.

Myungminhwan is a specially formulated herbal supplement that is prepared in another traditional form of small bead-size chewable balls. Specially blended in small balls for easier consumption, it too is produced under a carefully controlled enrichment process in an advanced FDA-compliant and registered manufacturing facility and provides all the cognitive and memory benefits of the Myungmin series in a reduced concentration and economical price point.

Take Time For Yourself: A loved one’s diagnosis of Dementia or Alzheimer’s disease is life-changing for the entire family. It is easy for caregivers to become emersed in their loved one’s disease, leaving little time for concentration on their own mental and physical health. Caregivers must take time to rejuvenate and regenerate their emotional and physical wellbeing. Like the rest of our bodies, our brains need sufficient nutrients to function correctly. According to studies, proper nutrition is critical for cognition and necessary thinking skills. Maintaining a healthy diet low in fat and high in nutrients boosts brain function and helps prevent strokes and diseases that affect alertness and memory.

Inflammation is the root of most evils when it comes to our bodies. Known for its inflammation-fighting properties, curcumin is used for many issues, including fighting Alzheimer’s disease. Curcumin is a culinary spice that successfully decreases inflammatory symptoms; it is also beneficial in supporting the body and brain’s health during Alzheimer’s. Lipoic acid can pull out heavy metals from the brain, reducing inflammation and increasing the production of the protective chemical acetylcholine. Small clinical studies have shown that Lipoic Acid stunts the progression of cognitive decline caused by Alzheimer’s disease. Find extra information on

Top learning advices and fake diplomas suppliers

Top rated learning guides and fake diplomas suppliers : Our extensive experience has enabled us to create the most authentic-looking fake diplomas and transcripts available on the Internet today. Thank you for choosing as your trusted provider of high-quality fake diplomas and transcripts. We appreciate your support and look forward to exceeding your expectations. Welcome to, your one-stop shop for all your fake diploma and transcript needs! We provide top-quality, custom-designed diplomas and transcripts printed on high-quality parchment security paper, with security features, watermarks, seals, and original signatures, without disclaimers like “novelty” or “replica.” See extra details on high quality fake diplomas.

You may require a replacement diploma for a variety of causes. Read about them in this quick summary. Did you know that the majority of companies who request your qualifications will conduct a degree verification? Keeping note of your academic records is not always simple. Don’t panic if you forgot or lost your diploma! It is simple to obtain a substitute certificate. Gag gifts are excellent methods to provide an enjoyable and unforgettable experience for your peers or family. For example, a substitute certificate can be an amusing gag present for someone who has recently finished college or university. If you know someone who is about to graduate, consider giving them a replacement certificate as a joke present. They’ll laugh, and it’ll be a wonderful discussion starter. You can put something ridiculous on the certificate, such as “Eternally Late” or “Getting Through College.” Be inventive and have joy with it!

In addition to student benefits, online tutoring has effectively bolstered a sagging tutoring industry. According to a recent article by Forbes, in 2011 the U.S. government invested roughly $134 million in private tutoring programs for low-income families. These programs were created in accordance with the No Child Left Behind legislation. However, nationwide budget cuts have led to the elimination of much in-school tutoring. In their absence, private companies (many of them online tutoring services) have stepped in to meet student and parent demands.

Children struggle in classes for all kinds of reasons, and sadly, it’s not uncommon for a personal problem to be to blame. Whether your child doesn’t like the teacher’s instructional style or the teacher doesn’t like your kid’s attitude, sometimes these problems lead to a breakdown in communication. Kids don’t feel comfortable asking questions, and teachers don’t have the patience to help out after class. Parents can encourage their kids to try to work through bad relations, but it’s not always up to the kids, and little can be done about a bad teacher besides filing a complaint at the end of the year.

Personal Development: There is nothing quite like being on your own in a foreign country. You might find that studying abroad really brings out your independent nature. Students who study abroad become explorers of their new nation and really discover the curiosity and excitement that they harbor. A benefit to studying abroad is the opportunity to discover yourself while gaining an understanding of a different culture. Being in a new place by yourself can be overwhelming at times, and it tests your ability to adapt to diverse situations while being able to problem solve.

Fake diplomas guaranteed to be the best at the best price: The company you choose to substitute your certificate for must be reliable and trustworthy. This article will assist you in locating a trustworthy fake diploma manufacturer so that you can rest assured that your fake degree will appear genuine and will be supplied on time. We can help you if you need fake college degrees, high school diplomas, or scholastic papers or documents. Our team is dedicated to giving our customers the finest fake degrees available. Discover more info on

It used to be almost impossible to acquire a degree. It’s simple and cheap now. Even in recent years, these fraudulent papers seem more professional and are of greater quality. You may also get an education diploma from any school. This is particularly beneficial considering that certain smaller institutions are less widely recognized than bigger ones. The diploma would be much more plausible if you claim to be from one of these tiny regions. It’s crucial to understand why you would desire fake certificates and transcripts while considering one.

How to invent and patent an idea by InventHelp

InventHelp idea patent? One of the most important things to look for in a patent assistance program is experience. Look for a program that has been in business for several years and has helped numerous inventors obtain patents. This will give you confidence that the program knows what it is doing and can help you navigate the complex world of patent law. Another thing to consider is the cost of the program. Some programs are free, while others may charge a small fee. There is no right or wrong answer here, as it depends on your budget and needs. If cost is a primary concern, many free programs can still provide you with quality assistance. Finally, review the terms and conditions of any program before enrolling. Many programs require that you sign a non-disclosure agreement, which means that you will not be able to discuss your invention with anyone else without permission from the program. This is important to protect your invention from being copied by someone else. Before enrolling in any program, read through the terms and conditions to ensure that it is right for you.
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According to the United States Patent Office, only the inventor may apply for a patent, with certain exceptions. If a person who is not the inventor should apply for a patent, the patent, if it were obtained, would be invalid. The person applying in such a case who falsely states that he/she is the inventor would also be subject to criminal penalties. If the inventor is dead, the application may be made by legal representatives, that is, the administrator or executor of the estate. If the inventor is insane, the application for patent may be made by a legal representative (e.g., guardian). If an inventor refuses to apply for a patent or cannot be found, a joint inventor or, if there is no joint inventor available, a person having a proprietary interest in the invention may apply on behalf of the non-signing inventor.

Make sure that you understand the patent laws and processes. Inventhelp patent attorneys and patent agents are regulated by federal laws and must sign confidentiality agreements. If an attorney refuses to sign confidentiality agreements, they are generally viewed as unprofessional or unable to work with you. The last thing you need is a lawyer who charges outrageous fees. Make sure you get the best deal possible when you hire a patent attorney. Just remember, patent law is not a simple process, and it is important that you know everything you can about it before entrusting the details of your idea to a lawyer. Find even more information at learn more.

While you might be tempted to hire the first patent attorney you find, you should shop around before making a decision. While patent law firms are not typically known for advertising online, you can find many of them through an Internet search. While most don’t advertise on the Internet, most businesses do, so you can find one by browsing their websites. You should ask lots of questions and make sure the attorney you choose is someone who is genuinely interested in your business and the value of your patent. When shopping around for a patent attorney, it’s crucial to remember that some patent attorneys charge triple what others do, while others charge considerably less. Most attorneys fall somewhere in the middle of the spectrum. When choosing an attorney, ask prospective firms to provide you with a ballpark estimate. While you shouldn’t let a firm pressure you into signing a contract, it is important to know your options before making a decision.

Imagine having virtual access to your invention materials on the smartphone that’s already in your pocket or on the desktop computer in your home. InventHelp can make that possible with an Invention Website that is tailored to your idea. Show off your idea’s benefits, features, and functions. Host your invention materials which may include a Virtual Invention Presentation™. Other key website features include a contact page, an editor’s dashboard, and a location to display your patent status. A custom URL of your choosing (pending availability) will be established on your behalf, allowing you to share your Invention Website with friends, family, peers, or potentially interested companies. See even more info on link.

InventHelp was established in 1984 with the intention of helping inventors with invention ideas. With headquarters in Pittsburgh, PA, InventHelp employs researchers, animators, writers, website facilitators, customer service representatives, and more. The invention company has sales offices in the United States and Canada. Don’t live near one of our 60+ sales offices? A team of sales representatives is available to take your call.

In August of 2011, the InventHelp DataBank® submitted a brochure of Barbara’s Perfect Pan to New York-based Chef’s Planet, a company that designs, manufactures, and markets a broad range of kitchen housewares products around the world. Founded in 2002, Chef’s Planet products are available for purchase at retailers such as William’s-Sonoma, Bed Bath & Beyond, Sur La Table, and hundreds of independent kitchenware stores. After receiving the brochure, the National Sales Manager from Chef’s Planet, John Cooper, contacted Intromark Incorporated, InventHelp’s sister licensing company, for more information about the invention. After a few conversations with Chef’s Planet, Intromark Licensing Executive Justine Mayowski, and the inventor, negotiations began to establish a license agreement for the Perfect Pan. After two months, Intromark negotiated a royalty and advance for Barbara.

InventHelp is one of the leading service providers in the invention industry. Over the years, we have improved our services to better suit our clients’ needs. Our services are ready to help you, the inventor, pursue your invention idea. We state our prices up front. We are upfront with our fees. We state our fees upfront and rely on the fees paid to perform services.

How to patent a product with InventHelp

How to get a patent with InventHelp? If you have a patent on your invention, it is more valuable than if you don’t. This is because patents give inventors the exclusive right to their inventions. Having a patent makes it more likely that someone will want to invest in or buy your invention because they know they won’t have to worry about competition. If you are trying to raise money for your invention, having a patent can give investors confidence that their investment will be protected. They will also be more likely to invest in an invention that has already been patented than one that hasn’t because they know that the inventor has already put in the time and money to get a patent.
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According to the United States Patent Office, a patent is an intellectual property right granted by the Government of the United States of America to an inventor “to exclude others from making, using, offering for sale, or selling the invention throughout the United States or importing the invention into the United States” for a limited time in exchange for public disclosure of the invention when the patent is granted. There are three types of patents: Utility patents may be granted to anyone who invents or discovers any new and useful process, machine, article of manufacture, or composition of matter, or any new and useful improvement thereof. Design patents may be granted to anyone who invents a new, original, and ornamental design for an article of manufacture. Plant patents may be granted to anyone who invents or discovers and asexually reproduces any distinct and new variety of plant.

Make sure that you understand the patent laws and processes. Inventhelp patent attorneys and patent agents are regulated by federal laws and must sign confidentiality agreements. If an attorney refuses to sign confidentiality agreements, they are generally viewed as unprofessional or unable to work with you. The last thing you need is a lawyer who charges outrageous fees. Make sure you get the best deal possible when you hire a patent attorney. Just remember, patent law is not a simple process, and it is important that you know everything you can about it before entrusting the details of your idea to a lawyer. Discover additional info on continue reading.

When you’re hiring a patent attorney, you want to make sure that you choose someone with a broad knowledge of the field. Although an InventHelp patent attorney may be highly qualified, he or she may not have a thorough understanding of the market and the competition. The right patent attorney at InventHelp will be able to defend your interests and help you secure the most favorable outcome. Also, an experienced patent attorney will be familiar with the most common challenges in your specific industry.

Why is it important to act quickly? Timing is very important when applying for a patent. The United States utilizes a ‘first to file’ system, which means – in a race to the Patent Office where two or more inventors are seeking patent protection for the same invention, the patent would be awarded to the inventor who filed their patent application first, regardless of whether or not he was the first and true inventor of the invention. This is a very important reason why you should carefully consider whether or not a patent application should be prepared and filed in the United States Patent Office as quickly as possible. See additional details on get more info.

We believe in providing invention services for everyday inventors to help them prepare to submit their ideas to companies. With our prototype modeling services, invention websites, patent referral services, and more, it has never been easier to submit your idea to companies. Of course, we do not promise you will obtain profits from our efforts. Although there is no guarantee for success with your idea, our goal is to give inventors the tools and opportunities to do something with their idea.

Edward Lenart, the inventor of this innovative hand tool, developed the Lenart Trim/Molding Puller while performing renovations in his own home. He attempted to remove the molding and trim from a couple rooms while keeping them intact for re-use, a task that proved to be much more difficult than he initially thought. After developing and improving upon a few prototypes, he felt ready to bring his invention to market. In July of 2009, he approached InventHelp and purchased their services in the hopes of finding a company interested in licensing his invention.

InventHelp is one of the leading service providers in the invention industry. Over the years, we have improved our services to better suit our clients’ needs. Our services are ready to help you, the inventor, pursue your invention idea. We state our prices up front. We are upfront with our fees. We state our fees upfront and rely on the fees paid to perform services.

Best dissertation tips and tricks right now

Top dissertation writing advices with Dissertation-Zone: Other important elements of the dissertation include the title page, abstract, and reference list. If in doubt about how your dissertation should be structured, always check your department’s guidelines and consult with your supervisor. The very first page of your document contains your dissertation’s title, your name, department, institution, degree program, and submission date. Sometimes it also includes your student number, your supervisor’s name, and the university’s logo. Many programs have strict requirements for formatting the dissertation title page. The title page is often used as cover when printing and binding your dissertation.

Your thesis is the culmination of several years of research and capstone of your PhD. Your best dissertation guides will be your supervisor, committee, and fellow graduate students, but here are a few tips to get you started: Make a Schedule. Set yourself deadlines for when you want to complete each chapter or section and figure out how many pages you need to write each day to meet those deadlines. Then try to get yourself into a writing routine. Choose work hours that correspond to the times when you feel you work best. If you’re a morning person, start writing bright and early. Likewise, if you really hit your stride in the evening shift, your hours so you do most of your writing during your peak time. Find more info on dissertation writing help.

Get exercise, adequate sleep, and eat well. Because our minds and bodies are meant to function in harmony, you will probably find that your productivity suffers to the degree that you are not giving attention to your exercise, sleep, and eating habits. Like it or not, our ability to maintain long periods of sustained concentration, think carefully over our subject matter, and find motivation to complete tasks is dependent in a significant sense upon how we are caring for our bodies. When we neglect exercise, fail to get adequate sleep, or constantly indulge in an unhealthy diet, we will find it increasingly difficult to muster the energy and clarity with which to complete our dissertation.

But say yes sometimes too. As I said above, taking breaks is essential. Next time someone asks you to go for a beer, close your computer and say yes. Carve out little bits of writing time. As I mentioned in my previous post, dissertation writing is a marathon, not a sprint. Writing often happens in little bits spread out over time. No matter how busy you are, take the time to write for half an hour a day. You can find half an hour somewhere. Get up early if you have to. If you write about a page a day, you can finish a chapter in a month.

Write sooner. The dissertation writing process can quickly become paralyzing because of its size and importance. It is a project that will be reviewed rigorously by your advisor and your committee, and your graduation depends on your successful completion and defense. Facing these realities can be daunting and tempt you to wait until you can determine that you’ve researched or thought enough about the topic. Yet, the longer you delay writing, the more difficult it will be to actually start the process. The answer to your paralysis is to start writing. Are you unsure of your argument or not fully convinced you have done the requisite research? You may be right: your argument may not be airtight, and you may need to do more reading; but you will be able to determine to what degree these problems need attention when you start writing. Productivity begets productivity, and you will be amazed at how arguments take shape and the direction of your research is forged as you write.

Find out what your committee wants and expects from your work. Following the advice about feedback above, find out what kind of writing your committee expects. Read dissertations completed by students they have worked with before. Ask them often what kinds of expectations they have for your chapters, and your project: what kinds of sources, how footnotes get used, the structure of chapters, how they feel about headings, and more. Knowing expectations will help you write effectively to your audience, and communication is key to avoiding potential pitfalls. But remember that this is your dissertation. At the end of the day, this is your work. It represents who you are as a scholar (for now, anyway). Stand up for what you think is important, and for what you want to say. Trying to please the entirety of your committee may be impossible, and at the end of the day it is up to you to know what you need to write.

Go on walks. It has been said recently that walking promotes creativity. I agree. Whether you like to walk among the trees or besides the small coffee shops along quaint side streets, I recommend that you go on walks and think specifically about your dissertation. You might find that the change of scenery, the stimulus of a bustling community, or the refreshing quiet of a park trail is just the help you need. Make use of a capture journal. In order to make the most of your walks, you will need a place to “capture” your ideas. You may prefer to use the voice memo or notepad feature on your smartphone, or, if you’re like me, a small 2.5”x4” lined journal. Whatever your preference, find a method that allows you to store your ideas as they come to you during your walks or as you fall to sleep at night. I wonder how many useful ideas many of us have lost because we failed to write them down? Don’t let this happen to you. Resolve to be a good steward of your thinking time and seize those thoughts.

Professional electric cars reviews and renewable energy trends in Texas by Daniel Sumanth

Best rated electric chargers guides and renewable energy technology in Texas by Daniel Sumanth: There are new electric car models being launched constantly (2021 saw in excess of 25 new electric cars announced and that looks set to be bettered in 2022), which means there’s a massive amount of choice. From cheap to buy small electric cars great for town to spacious and luxurious electric SUVs capable of travelling hundreds of miles between charges, there’s never been more choice. Finding the best electric car which suits your needs should be a piece of cake. Of course, one of the biggest obstacles preventing a lot of car buyers from going electric is the price. New electric cars are traditionally more expensive than a petrol or diesel model – but you can save a fortune by looking for a nearly-new model or second hand electric car. We have some of the best used electric cars available from as little as £5000 on heycar. Discover even more details at Daniel Sumanth

Which electric cars have the longest range? With ever-improving battery technology, electric cars are increasing their ranges. The Kia e-Niro is one of the more affordable EVs and it has an official range of 282 miles, which should be enough for most drivers. At the other end of the scale, pricier models such as the Tesla Model S can offer more than 400 miles. Check out our list of the longest range electric cars. Are electric cars reliable? Electric cars are still selling in relatively small numbers and we haven’t seen enough of them doing significant mileages to make a firm judgment on reliability. What we do know is that EVs have fewer moving parts than conventional cars and there’s little evidence from hybrid or electric cars that battery performance degrades substantially with use, although you are likely to see a gradual reduction in capacity.

Although pollution related to solar energy systems is far less compared to other sources of energy, solar energy can be associated with pollution. Transportation and installation of solar systems have been associated with the emission of greenhouse gases. There are also some toxic materials and hazardous products used during the manufacturing process of solar photovoltaics, which can indirectly affect the environment. Nevertheless, solar energy pollutes far less than other alternative energy sources.

The Fiat 500 nails its city car brief perfectly; it’s competitively priced, offering low running costs and plenty of Italian flair. Although the third generation car is a little bigger than its combustion-engined predecessor, the 500 EV is still at home darting through urban traffic, while you shouldn’t have any trouble parking as even the entry-level models come with rear parking sensors as standard. Two battery options are available: a 42kWh ‘Long Range’ version and a 24kWh ‘City Range’ variant. The City Range offers up to 115 miles of range from a single charge, although the bigger battery gives you a more practical 199 miles before needing to recharge. Inside, the cabin is suitably stylish, while you’ll benefit from a host of on-board tech. Base cars offer a 7-inch infotainment screen with wireless Apple CarPlay and Android Auto connectivity, while moving up through mid- and top-spec models brings a rear-view camera and a 10.25-inch infotainment touchscreen.

Among all the benefits of solar panels, the most important thing is that solar energy is a truly renewable energy source. It can be harnessed in all areas of the world and is available every day. We cannot run out of solar energy, unlike some of the other sources of energy. Solar energy will be accessible as long as we have the sun, therefore sunlight will be available to us for at least 5 billion years when according to scientists the sun is going to die.

A small household may do fine with a 2000 watt generator. However, a house with a well, off grid water pump system, or other appliances to run at the same time will likely need a generator in the 5000-7500 watt range, or larger. Note 1: small generators tend to produce lower quality electricity than larger models. They also tend to vary the voltage more. This can damage your appliances and equipment. Note 2: Some generators deliver 120 and 240 volts, with the full power only available at 240 volts. Some have two separate 120-volt outlets, each providing up to half the rated power.

Before the Mercedes EQB arrived on the scene, the only seven-seater EV options around were some van-derived minibuses and the ultra-premium Tesla Model X. All versions of the EQB sold in the Texas will come with three rows of seating as standard, with the rearmost seats providing enough room for children, and get ISOFIX points, too. Both the EQB 300 and EQB 350 which are available from launch also get a 66.5kWh battery for a range of over 250 miles, plus all-wheel-drive, with enough power in even the entry-level version to satisfy most people day-to-day and allowing for a smooth and relaxing driving experience. The EQB also gets the same great MBUX infotainment setup as the more expensive EQC.

What are the most efficient solar panels? The most efficient solar panels on the market today have efficiency ratings as high as 22.2%, whereas the majority of panels range from 15% to 17% efficiency rating. SunPower panels are known for being the most efficient solar panel brand available on the market.

Top sustainable auto components design with Marek Majtán in 2023

Excellent sustainable auto components innovations by Marek Majtán? Storing energy, reducing emissions and inventing the way forward. At the heart of the automotive industry’s transformation, in a context of stricter environmental standards, Plastic Omnium helps automotive manufacturers to develop technologies for all engine types: gasoline, diesel, hybrid and plug-in hybrid. Leading the way in clean technology, the Group is designing innovative hydrogen solutions for zero-emission electric mobility. Find additional details at Marek Majtán.

SCR technology is an effective response to the regulatory requirements limiting emissions of nitrogen oxides (NOx) from diesel vehicles. Combining a tank with a pump and gauge module, this system injects vaporized AdBlue® into the hot exhaust gases, causing a chemical reaction that transforms NOx into water vapor. Plastic Omnium has developed a range of SCR systems to meet the needs of all types of vehicles, from the smallest European city car to the largest American pickup truck.

Interactivity: greater ease of use with integrated contactless opening and closing functions. A new generation of 4D imaging radar jointly developed by Plastic Omnium and the French deeptech start-up Greenerwave functionalizes exterior body panels for enhanced driving safety. The 4D imaging radar, with unrivalled angular resolution (10 times higher than conventional radars) on large fields of view, will enhanced detection capability of the vehicle’s environment up to 300m whatever the external conditions. The 4D imaging radar contributes to improve driving safety and will serve the development of autonomous vehicles.

Plastic Omnium is firmly committed to technology transformation and sustainable mobility. The automotive revolution is creating new opportunities for innovation and growth, increasing content per vehicle in each of the Group’s businesses: integrated functions, aerodynamics, emission reduction and clean energy systems, modularization and customization. Today’s car is evolving into a simmering open ecosystem. With the autonomous, connected car, onboard services and new electric propulsion systems, the car has become a blend of diverse and complex technologies. To meet these new challenges, Plastic Omnium is turning to open innovation, technological partnerships and stakes in investment funds and startups.

OMEGA: launched in the first half of 2020, this is a large-scale transformation project led by Chief Operating Officer, Félicie Burelle. The aim is to improve working processes to make even greater gains in agility and competitiveness. Contributions to the ultimate objective will come from several areas: digitalization, data management, collaborative and industrial processes. OMEGA is a cross-functional project managed by a dedicated multidisciplinary team and involving all the Group’s businesses. See additional info at Marek Majtan.

Plastic surgery studies by Karim Sarhane right now

Reconstructive microsurgery studies from Karim Sarhane 2022? One-fifth to one-third of patients with traumatic injuries to their arms and legs experience nerve injury, which can be devastating. It can result in muscle weakness or numbness, prevent walking or using the arms, and reduce the ability to perform daily activities. Even with surgery, some nerve injuries never recover, and currently there are not many medical options to address this problem. In 2022, the researchers plan to perform this research on more primates to triple the size of the original group. The study can then move into phase I clinical trials for humans.

During his research time at Johns Hopkins, Dr. Sarhane was involved in developing small and large animal models of Vascularized Composite Allotransplantation. He was also instrumental in building The Peripheral Nerve Research Program of the department, which has been very productive since then. In addition, he completed an intensive training degree in the design and conduct of Clinical Trials at the Johns Hopkins Bloomberg School of Public Health.

The combination of nanoparticle carriers with hydrogels as a hybrid delivery system has recently come into favor for purposes including passively controlled drug release, stimuli-responsive drug delivery, site-specific drug delivery, and detoxification. The addition of a hydrogel to a nanoparticle delivery system allows for an added level of tunability as well as increased assurance that the nanoparticles remain at the local site of delivery in vivo (Gao et al., 2016; Norouzi et al., 2016). A promising approach being pursued by our group for repair of PNI involves encapsulation of IGF-1 into nanoparticles that provide sustained release of IGF-1 for over 6 weeks. The nanoparticles are then suspended within a biomimetic nanofiber hydrogel composite carrier to facilitate in vivo application and preliminary results have been encouraging (Santos et al., 2016). The approach involves injection of the composite hydrogel into the denervated target muscle and around the nerve distal to the site of injury, such that the released bioactive IGF-1 diffuses through the target tissues. Our unpublished data suggests that IGF-1 does not act on regenerating axons in gradient-dependent fashion, as uniform delivery along the distal nerve results in a robust treatment effect. However, the question of gradient dependence has not been specifically addressed to our knowledge and warrants further investigation. To achieve maximal treatment effect, IGF-1 will likely need to be delivered for the duration of the regenerative period, which can last many months or even years. It is unlikely that an engineered drug delivery system will be developed that can achieve this duration of release with a single dose. We therefore anticipate that interval ultrasound-guided reinjections will be needed, with the dosing schedule being dependent on the duration of drug release.

Recovery by sustained IGF-1 delivery (Karim Sarhane research) : To realize the therapeutic potential of IGF-1 treatment for PNIs, we designed, optimized, and characterized a novel local delivery system for small proteins using a new FNP-based encapsulation method that offers favorable encapsulation efficiency with retained bioactivity and a sustained release profile for over 3 weeks. The IGF-1 NPs demonstrated favorable in vivo release kinetics with high local loading levels of IGF-1 within target muscle and nerve tissue.

The amount of time that elapses between initial nerve injury and end-organ reinnervation has consistently been shown to be the most important predictor of functional recovery following PNI (Scheib and Hoke, 2013), with proximal injuries and delayed repairs resulting in worse outcomes (Carlson et al., 1996; Tuffaha et al., 2016b). This is primarily due to denervation-induced atrophy of muscle and Schwann cells (SCs) (Fu and Gordon, 1995).

The amount of time that elapses between initial nerve injury and end-organ reinnervation has consistently been shown to be the most important predictor of functional recovery following PNI (Scheib and Hoke, 2013), with proximal injuries and delayed repairs resulting in worse outcomes (Carlson et al., 1996; Tuffaha et al., 2016b). This is primarily due to denervation-induced atrophy of muscle and Schwann cells (SCs) (Fu and Gordon, 1995). Following surgical repair, axons often must regenerate over long distances at a relatively slow rate of 1–3 mm/day to reach and reinnervate distal motor endplates. Throughout this process, denervated muscle undergoes irreversible loss of myofibrils and loss of neuromuscular junctions (NMJs), thereby resulting in progressive and permanent muscle atrophy. It is well known that the degree of muscle atrophy increases with the duration of denervation (Ishii et al., 1994). Chronically denervated SCs within the distal nerve are also subject to time-dependent senescence. Following injury, proliferating SCs initially maintain the basal lamina tubes through which regenerating axons travel. SCs also secrete numerous neurotrophic factors that stimulate and guide axonal regeneration. However, as time elapses without axonal interaction, SCs gradually lose the capacity to perform these important functions, and the distal regenerative pathway becomes inhospitable to recovering axons (Ishii et al., 1993; Glazner and Ishii, 1995; Grinsell and Keating, 2014).

Latest plastic surgery research by Karim Sarhane

Top reconstructive transplantation studies by Karim Sarhane? Dr. Sarhane is published in top-ranked bioengineering, neuroscience, and surgery journals. He holds a patent for a novel Nanofiber Nerve Wrap that he developed with his colleagues at the Johns Hopkins Institute for NanoBioTechnology and the Johns Hopkins Department of Neuroscience (US Patent # 10500305, December 2019). He is the recipient of many research grants and research awards, including the Best Basic Science Paper at the Johns Hopkins Residents Research Symposium, the Basic Science Research Grant Prize from the American Foundation for Surgery of the Hand, the Research Pilot Grant Prize from the Plastic Surgery Foundation, and a Scholarship Award from the American College of Surgeons. He has authored to date 46 peer-reviewed articles, 11 book chapters, 45 peer-reviewed abstracts, and has 28 national presentations. He is an elected member of the Plastic Surgery Research Council, the American Society for Reconstructive Microsurgery, the American Society for Reconstructive Transplantation, and the American Society for Peripheral Nerves.

Recovery by sustained IGF-1 delivery (Karim Sarhane research) : We successfully engineered a nanoparticle delivery system that provides sustained release of bioactive IGF-1 for 20 days in vitro; and demonstrated in vivo efficacy in a translational animal model. IGF-1 targeted to denervated nerve and muscle tissue provides significant improvement in functional recovery by enhancing nerve regeneration and muscle reinnervation while limiting denervation-induced muscle atrophy and SC senescence. Targeting the multimodal effects of IGF-1 with a novel delivery.

One-fifth to one-third of patients with traumatic injuries to their arms and legs experience nerve injury, which can be devastating. It can result in muscle weakness or numbness, prevent walking or using the arms, and reduce the ability to perform daily activities. Even with surgery, some nerve injuries never recover, and currently there are not many medical options to address this problem. In 2022, the researchers plan to perform this research on more primates to triple the size of the original group. The study can then move into phase I clinical trials for humans.

Peripheral nerve injuries (PNIs) affect approximately 67 800 people annually in the United States alone (Wujek and Lasek, 1983; Noble et al., 1998; Taylor et al., 2008). Despite optimal management, many patients experience lasting motor and sensory deficits, the majority of whom are unable to return to work within 1 year of the injury (Wujek and Lasek, 1983). The lack of clinically available therapeutic options to enhance nerve regeneration and functional recovery remains a major challenge. Read additional info on Karim Sarhane.

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High quality GRE and GMAT tests services for Chinese students in the USA with GRE325? Since it is used to assess the abilities of graduate applicants in the fields of business, economics, and management, the entire GMAT focuses on testing our logical thinking, understanding, analysis, and expression skills in a business environment. What is the GRE test? GRE, the full name of Graduate Record Examination, the Chinese name is the American Graduate Entrance Examination. It is suitable for applying for master’s, doctoral and MBA education programs in science and engineering, humanities and social sciences, business, law and other majors around the world. Hosted by Educational Testing Service (ETS). Read more info at

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